ABSTRACT
Objective To investigate the clinical effect of lumbar catheter drainage combined with intrathecal injection on patients with cerebrospinal fluid leakage and intracranial infection.Methods A retrospective study was conducted.One hundred and fifty-two cases with cerebrospinal fluid leakage and intracranial infection were selected as our subjects who were hospitalized in the First Hospital of Yuncheng from 2006 to 2014.The patients were divided into lumbar puncture + intrathecal group (A),lumbar (group B) and lumbar intrathecal large pool + group (group C) based on post-processing methods.A experimental data were recorded and compared in terms of the total efficiency of treatment,the therapeutically effective time,bacterial clearance and security differences.Results After treatment,the levels of white blood cells,protein,glucose and intracranial pressure were changed compared with that of before treatment in three group(P ＜ 0.01),but there was no significant difference among the three groups(P ＞ 0.05).The therapy periods in group A,group B and group C were (12.80 ± 2.25) d,(12.64 ± 2.00) d and (9.44 ± 1.50) d respectively and the difference was significant(F =25.94,P ＜ 0.05).Compared with Group C,the therapy periods in group A and B were significant different(t =2.769,2.854;P ＜ 0.05),but there was no significant difference between group A and B (t =0.119,P =0.908).The cases with success.effect was 45 (89.1％) in group A,53 (94.6％) in group B,46 (95.8％) in group C,and there was no significant difference among three groups (P ＞ 0.05).In terms of bacterial clearance rate,33 cases(68.75％) was in group A,35 cases(72.91％) in group C and 23 cases (41.07％) in group B and the effective rate in group A or C were higher than that in group B (x2 =9.478,10.63 ; P ＜ 0.05).Conclusion The methods of lumbar catheter drainage combinedwith intrathecal injection is proved with a high clinical value of therapy,effective treatment can effectively shorten the time and improve the overall treatment effect.
ABSTRACT
Objective To investigate the clinical efficacy of minimally invasive surgery for hypertensive intracerebral hemorrhage (HIH).Methods retrospectively analyzed the clinical data of 82 patients with HIH from March 2009 to May 2012,of43 patients in the observation group with minimally invasive surgery and 39 cases were treated with traditional craniotomy in control group.Comparing the two groups of patients with angiotensin system related indexes and 3 d internal pressure.Results The renin,angiotensin Ⅱ and aldosterone of observation group were (1.1 ±0.2) μg/(L · h),(56.7 ± 12.0) ng/L and (119.2 ± 15.6) ng/L respectively,while in control group were (2.1 ± 0.6) μg/(L · h),(77.4 ± 12.5) ng/L and (150.3 ± 22.4)ng/L respectively,there was a significant difference compared with the control group (t =6.74,8.93,5.61,respectively,P ＜ 0.05).The systolic blood pressure (SBP) preoperative and postoperative 1,2,3 days of observed group were (188 ± 12) mm Hg,(166 ± 10) mm Hg,(153 ± 9) mm Hg,(145 ± 9) mm Hg,while of control group were (189±17) mm Hg,(183 ±16) mm Hg,(179±15) mm Hg,(168±15) mm Hg(P＜0.05).The difference was statistically significant (F in group =19.41,P ＜ 0.05;F between group =21.33,P ＜0.05 ;F interactive group =17.56,P ＜ 0.05),and the observation changes of SBP were stable than the control group.Conclusion Minimally invasive operation in the treatment of HIH,can effectively control the systolic blood pressure levels.Patients recovered quickly,and of which the prognosis was good.